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blood glucose so that the glucose infusion rate can be accurately titrated. Soluble insulin is infused intravenously at a xed rate of 50 mU/kg/h into one arm, together with an infusion of 20% glucose at a variable rate, adjusted on the basis of blood glucose levels (sampled from the other arm) every 5 minutes, to keep blood glucose within the range 4 7 mmol/l. The infusions are continued for 3 hours and steady-state is assumed during the last 30 minutes, when the glucose infusion rate and nal blood glucose concentration are measured (Figure 3.15). Insulin sensitivity can be expressed simply as the average glucose infusion rate during the last 30 minutes of the clamp which, at a steady rate, equals the glucose disposal rate. Alternatively, the glucose metabolic clearance rate (Gmcr) can be derived as (glucose disposal rate)/(steady-state blood glucose level), and the insulin sensitivity index (SI) as (glucose disposal rate)/(steady-state plasma insulin concentration). The EHC is generally regarded as the most reliable method for determining insulin sensitivity, and is the gold-standard used to validate other techniques. However, the steady-state insulin concentrations achieved are supraphysiological, and assumptions about glucose disposal break down if individuals lose substantial amounts of glucose in the urine, or (as may happen in cases

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Fig. 3.4 Directional patterns of a delay beamformer for 11 frequencies uniformly distributed from 55 to 65 kHz.

Figure 16-7: The point objects were used as the pick points. These are the fit points of the spline.

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It is worth noting that the transfer of risk, or allocation to another party, can be accomplished either explicitly through drafted and agreed contract wording, or implicitly if the entity responsible for the risk is expected to have a level of capability or professional skills in that area Implicit transfer of risks is, of itself, a more risky approach as this relies upon unwritten or implied conditions..

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The last two chapters discussed PDF file creation using Adobe Acrobat and Acrobat Distiller. If you ve read those chapters, you ve learned when to use Distiller over other methods. Yet another means of creating PDF files is with direct exports from application software programs. Adobe Systems has been implementing PDF support for some time in many of its design applications and other vendors are continually providing support. Early methods for creating these exports were fairly simple in that they were similar to the way PDFWriter generated PDF files. Current methods rely on more sophisticated approaches that offer control over font embedding, compression, and advanced Job Options. It stands to reason that the software manufacturer that has implemented the best PDF integration with other programs is Adobe Systems. The new PDF support for Illustrator 9.0, InDesign 1.5, and Photoshop 6.0 are applications all developed around core PDF architecture. The integration of PDF between these programs is now seamless and offers opportunity to create, edit, and import PDFs with consistent reliability. Other software manufacturers are also adding more support with every program upgrade. Manufacturers, such as Corel Corporation, Macromedia, and Quark, Inc., also implement PDF support in their recent program releases. At times, there may be a need to create PostScript files and use Distiller with one program or another. Most often though, you ll find the advanced, professional application software well suited and often preferred in producing PDF files.

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3 Switch to the Sprites tab to build the stage for your animation Make the following choices: Visible enables you to have your sprite track appear when the movie begins, or be invisible upon playback By default, this is checked and the sprite track is visible (Apparently, the Eye icon in the TimeLine window has an adverse effect on sprites, boundary-wise) Scale Sprites When Track Is Resized enables images to scale the way they re designed to Background Color enables you to set a color other than the default black The color swatch here works like the usual GoLive feature, so click to bring up the Color palette, and then click the color to set it Your color will not appear in the Movie window yet 4.

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